Modifiers of mutant huntingtin aggregationfunctional conservation of C. elegans-modifiers of polyglutamine aggregation
نویسندگان
چکیده
منابع مشابه
RNAi Screening in Drosophila Cells Identifies New Modifiers of Mutant Huntingtin Aggregation
The fruitfly Drosophila melanogaster is well established as a model system in the study of human neurodegenerative diseases. Utilizing RNAi, we have carried out a high-throughput screen for modifiers of aggregate formation in Drosophila larval CNS-derived cells expressing mutant human Huntingtin exon 1 fused to EGFP with an expanded polyglutamine repeat (62Q). 7200 genes, encompassing around 50...
متن کاملacquisition of noun modifiers by persian(l1) learners of english (l2) and french (l3)
توجه این تحقیق بر موضوع یادگیری زبان سوم بوده ونقش زبان های پیشین در یادگیری زبان جدید را بررسی میکند. بدین منظور، بعضی از ساختارهای توصیف کننده های اسمی همانند اسم بعد از اعداد جمع و صفت های شمارشی، صفات توصیفی،و صفات ملکی انتخاب شدند. سه زبان مورد بررسی فارسی (زبان اول)، انگلیسی (زبان دوم)، و فرانسه (زبان سوم) بودند. هدف، تعیین میزان مراجعه زبان آموزان به زبان های اول و دومشان در یادگیری ساخت...
15 صفحه اولA genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.
Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a model organism that has been applied extensively in modeling NDs and screening for toxicity modifie...
متن کاملA Genome-wide RNAi Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila
A Genome-wide RNAi Screen for Modifiers of Aggregates Formation by Mutant Huntingtin in Drosophila Sheng Zhang , Richard Binari , Rui Zhou and Norbert Perrimon * Department of Genetics and Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA Current address: Research Center for Neurodegenerative Diseases, the Brown Foundation Institute of Molecular Medicine, the Univers...
متن کاملHuntingtin Interacting Proteins Are Genetic Modifiers of Neurodegeneration
Huntington's disease (HD) is a fatal neurodegenerative condition caused by expansion of the polyglutamine tract in the huntingtin (Htt) protein. Neuronal toxicity in HD is thought to be, at least in part, a consequence of protein interactions involving mutant Htt. We therefore hypothesized that genetic modifiers of HD neurodegeneration should be enriched among Htt protein interactors. To test t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Currents
سال: 2011
ISSN: 2157-3999
DOI: 10.1371/currents.rrn1255